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However, little is known about how maternal gut microbiota influences feto-placental growth and placental structure and function. Studies performed with germ-free (GF) mice have identified that the microbiota is a key regulator for adequate development, early immune education and metabolism. Knowledge in this area would be highly valuable for developing treatments to improve fetal growth, with benefits for population health.
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However, the contribution of the maternal gut microbiota in determining fetal outcomes is largely unexplored.
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Failure of the mother to provide nutrients and metabolites to the fetus can result in pregnancy complications including small for gestational age, fetal loss and stillbirth. Notably, there are also alterations in the maternal microbiota throughout pregnancy with levels of the bacterial genus Bifidobacterium rising from trimester 1 onwards. This is highly important across gestation, particularly at later stages, when fetal growth is maximal. During gestation, liberated metabolites may be used by the placenta for morphogenesis, and transported across the placenta for use by the fetus for growth and development. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.Īll nutrients and metabolites required for feto-placental growth are provided by the mother, which in turn is thought to be influenced by the maternal gut microbiota through the breakdown of complex dietary components. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Maternal and placental metabolome were affected by maternal gut microbiota ( i.e.
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Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth.
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System requirements: - Intel Pentium 4 processor (multiprocessor systems recommended) - 512 MB RAM (1GB or more recommended) - 500 MB free hard disk space (10GB for productive work) - Apple QuickTime 6.5 (higher recommended) - DVD-ROM drive - graphics card that supports 24-bit color Attention! Due to the size of the file it is recommended to download one of the download accelerators to download one of them, go to the appropriate category: Download Files.The gut microbiota plays a central role in regulating host metabolism.
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